Microscopy imaging reveals changes in aging brain's vascular system
In vivo imaging helps determine detailed changes in aged brains
Researchers have utilized mesoscale microscopy methods and in vivo imaging to determine detailed changes in the vascular system of aged brains. The cerebral functional reorganization and declined cognitive function of aging might be associated with these observed changes.
Aging is the largest risk factor for neurodegenerative disorders and is commonly associated with a decline in cognitive function. The brains vascular system is highly organized to efficiently deliver oxygen and glucose to its many cells. Previous studies have shown that the brains vascular system undergoes structural and functional changes during aging, but the details of these changes have not been fully understood.
In this study, researchers used mesoscale microscopy to image the brains vascular system in live mice. They found that the vascular system of aged mice had a number of abnormalities, including decreased density of blood vessels, increased tortuosity of blood vessels, and impaired blood flow. These changes were most pronounced in the hippocampus, a brain region that is involved in learning and memory.
The researchers also found that the vascular system of aged mice was more susceptible to damage. They induced a stroke in mice and found that the brains of aged mice had more severe damage than the brains of young mice. This suggests that the vascular system of aged brains is more vulnerable to injury.
These findings provide new insights into the changes that occur in the brains vascular system during aging. They could lead to the development of new treatments for age-related cognitive decline and neurodegenerative disorders.
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